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Abstract People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in theN-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgGN-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH. 

An analytical model for reflection of a reconfigurable intelligent surface (RIS) using varactors to adjust the reflection phase of an incident plane wave is presented. The model results are compared to a full-wave RIS simulation for different varactor bias voltages. The model is intended to be analytical and simple enough, but related to a realistic RIS, to be inserted into MIMO wireless systems algorithms to estimate the propagation channel including the RIS. 

We present a catalog of results of gamma-ray observations made by VERITAS, published from 2008 to 2020. VERITAS is a ground based imaging atmospheric Cherenkov telescope observatory located at the Fred Lawrence Whipple Observatory (FLWO) in southern Arizona, sensitive to gamma-ray photons with energies in the range of ∼ 100 GeV - 30 TeV. Its observation targets include galactic sources such as binary star systems, pulsar wind nebulae, and supernova remnants, extragalactic sources like active galactic nuclei, star forming galaxies, and gamma-ray bursts, and some unidentified objects. The catalog includes in digital form all of the high-level science results published in 112 papers using VERITAS data and currently contains data on 57 sources. The catalog has been made accessible via GitHub and at NASA's HEASARC. 

Abstract The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a drift scan radio telescope operating across the 400–800 MHz band. CHIME is located at the Dominion Radio Astrophysical Observatory near Penticton, BC, Canada. The instrument is designed to map neutral hydrogen over the redshift range 0.8–2.5 to constrain the expansion history of the universe. This goal drives the design features of the instrument. CHIME consists of four parallel cylindrical reflectors, oriented north–south, each 100 m × 20 m and outfitted with a 256-element dual-polarization linear feed array. CHIME observes a two-degree-wide stripe covering the entire meridian at any given moment, observing three-quarters of the sky every day owing to Earth’s rotation. An FX correlator utilizes field-programmable gate arrays and graphics processing units to digitize and correlate the signals, with different correlation products generated for cosmological, fast radio burst, pulsar, very long baseline interferometry, and 21 cm absorber back ends. For the cosmology back end, the $N_{\mathrm{feed}}^2$correlation matrix is formed for 1024 frequency channels across the band every 31 ms. A data receiver system applies calibration and flagging and, for our primary cosmological data product, stacks redundant baselines and integrates for 10 s. We present an overview of the instrument, its performance metrics based on the first 3 yr of science data, and we describe the current progress in characterizing CHIME’s primary beam response. We also present maps of the sky derived from CHIME data; we are using versions of these maps for a cosmological stacking analysis, as well as for investigation of Galactic foregrounds.