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An analytical model for reflection of a reconfigurable intelligent surface (RIS) using varactors to adjust the reflection phase of an incident plane wave is presented. The model results are compared to a full-wave RIS simulation for different varactor bias voltages. The model is intended to be analytical and simple enough, but related to a realistic RIS, to be inserted into MIMO wireless systems algorithms to estimate the propagation channel including the RIS. 

Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and signaling molecule. However, the targets of heme signaling and the network of proteins that mediate the exchange of heme from sites of synthesis or uptake to heme dependent or regulated proteins are poorly understood. Herein, we describe a quantitative mass spectrometry (MS)-based chemoproteomics strategy to identify exchange labile hemoproteins in human embryonic kidney HEK293 cells that may be relevant to heme signaling and trafficking. The strategy involves depleting endogenous heme with the heme biosynthetic inhibitor succinylacetone (SA), leaving putative heme-binding proteins in their apo-state, followed by the capture of those proteins using hemin–agarose resin, and finally elution and identification by MS. By identifying only those proteins that interact with high specificity to hemin–agarose relative to control beaded agarose in an SA-dependent manner, we have expanded the number of proteins and ontologies that may be involved in binding and buffering labile heme or are targets of heme signaling. Notably, these include proteins involved in chromatin remodeling, DNA damage response, RNA splicing, cytoskeletal organization, and vesicular trafficking, many of which have been associated with heme through complementary studies published recently. Taken together, these results provide support for the emerging role of heme in an expanded set of cellular processes from genome integrity to protein trafficking and beyond.

 

We present a catalog of results of gamma-ray observations made by VERITAS, published from 2008 to 2020. VERITAS is a ground based imaging atmospheric Cherenkov telescope observatory located at the Fred Lawrence Whipple Observatory (FLWO) in southern Arizona, sensitive to gamma-ray photons with energies in the range of ∼ 100 GeV - 30 TeV. Its observation targets include galactic sources such as binary star systems, pulsar wind nebulae, and supernova remnants, extragalactic sources like active galactic nuclei, star forming galaxies, and gamma-ray bursts, and some unidentified objects. The catalog includes in digital form all of the high-level science results published in 112 papers using VERITAS data and currently contains data on 57 sources. The catalog has been made accessible via GitHub and at NASA's HEASARC. 

The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a drift scan radio telescope operating across the 400–800 MHz band. CHIME is located at the Dominion Radio Astrophysical Observatory near Penticton, BC, Canada. The instrument is designed to map neutral hydrogen over the redshift range 0.8–2.5 to constrain the expansion history of the universe. This goal drives the design features of the instrument. CHIME consists of four parallel cylindrical reflectors, oriented north–south, each 100 m × 20 m and outfitted with a 256-element dual-polarization linear feed array. CHIME observes a two-degree-wide stripe covering the entire meridian at any given moment, observing three-quarters of the sky every day owing to Earth’s rotation. An FX correlator utilizes field-programmable gate arrays and graphics processing units to digitize and correlate the signals, with different correlation products generated for cosmological, fast radio burst, pulsar, very long baseline interferometry, and 21 cm absorber back ends. For the cosmology back end, the$N_{\mathrm{feed}}^2$correlation matrix is formed for 1024 frequency channels across the band every 31 ms. A data receiver system applies calibration and flagging and, for our primary cosmological data product, stacks redundant baselines and integrates for 10 s. We present an overview of the instrument, its performance metrics based on the first 3 yr of science data, and we describe the current progress in characterizing CHIME’s primary beam response. We also present maps of the sky derived from CHIME data; we are using versions of these maps for a cosmological stacking analysis, as well as for investigation of Galactic foregrounds.